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JWH-250 or (1-pentyl-3-(2-methoxyphenylacetyl)indole)  is a full agonist synthetic cannabinoid first synthesized by organic chemist john w. huffman. it gained popularity in late 2008 when german chemists found it as a chemical within the popular synthetic cannabis blend spice, which had been sold in numerous countries around the world since 2002. Cannabinoids are commonly smoked or vaporized to achieve a quick onset of effects and rapid offset. jwh-018 is orally active when dissolved in a lipid, which can increase the duration significantly. like other cannabinoids, it is insoluble in water but dissolves in ethanol and lipids. Unlike cannabis, the chronic abuse of synthetic cannabinoids has been associated with multiple health effects and toxicity in general but JWH Helps For Depression, Anxiety, Disorders, Sleeplessness.


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JWH-250 (1-pentyl-3-(1-naphthoyl)indole) or AM-678 is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with some selectivity for CB2. It produces effects in animals similar to those of tetrahydrocannabinol (THC), a cannabinoid naturally present in cannabis, leading to its use in synthetic cannabis products that in some countries are sold legally as “incense blends”. As a full agonist at both the CB1 and CB2 cannabinoid receptors, this chemical compound is classified as an analgesic medication. The analgesic effects of cannabinoid ligands, mediated by CB1 receptors are well established in treatment of neuropathic pain, as well as cancer pain and arthritis. These compounds work by mimicking the body’s naturally-produced endocannabinoid hormones such as 2-AG and anandamide (AEA), which are biologically active and can exacerbate or inhibit nerve signaling. As the cause is poorly understood in chronic pain states, more research and development must be done before the therapeutic potential of this class of biologic compounds can be realized.


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jwh-250, or naphthalen-1-yl-(1-pentylindol-3-yl)methanone, is a synthetic cannabinoid containing a substituted indole structure. this indole core is shared with other cannabinoid substances including pb-22, 5f-pb-22, jwh-018, and am2201. jwh-018 is substituted at r1 with a pentyl chain. additionally, the indole core is substituted at r3 with a carbonyl group which is also bonded to a napthalene moeity. napthalene is a bicyclic structure of two fused benzene rings. this carbonyl bridge of jwh-018 classifies it as a ketone. jwh-018 is an analog of thj-018, in which the core indazole structure is substituted with an indole base. jwh 018 incense, herbal incense with jwh-018 for sale, how to make herbal incense with jwh-018, jwh-018 incense, how to make jwh 018 incense, synthetic cannabinoid spray, buy synthetic cannabinoid spray, what do i combine with synthetic cannabinoid to make a spray. K2 synthetic cannabinoid, K2 synthetic cannabinoid, buy synthetic cannabinoid chemicals.


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In July, 2009, the US Drug Enforcement Agency (DEA) listed JWH-250 on its Drugs and Chemicals of Concern list. In addition to reported seizures of Spice in Ohio and Florida, several states have passed legislative action restricting the sale or possession of JWH-018 including Alabama, Arkansas, Georgia, Kansas, Kentucky, North Dakota, and Tennessee.


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